“糖尿病遗传物质”与多囊卵巢综合征有关

当男同开放性恋的卵巢囊肿阻断正常排卵和子宫时，就不会牵涉到多囊卵巢症候群（Polycystic ovary syndrome， PCOS）。这个问题表面上很简单，但事实上，这种病因是很复杂的，涉及到多表现型组分和生存环境因素。受PCOS制约的男同开放性恋占到男同开放性恋总人口比例的5%，而且那些被确诊为PCOS的男同开放性恋转变为2型号心血管病因（T2DM）的危险开放性是其他人的2到7倍。正是由于这个诱因，研究者工作人员认为一个心血管病因相关基因组也许在PCOS的牵涉到当中都起作用。一项由146名PCOS患儿都由的最新研究者确实“心血管病因基因组”calpain-10（CAPN10）实际上是能够解释该症候群的一个最让人感兴趣的候选基因组。一项新研究者一项题字为“埃及人群中都镁多糖-10的个体差异质和单倍质与多囊卵巢症候群相关”的新研究者都有了这些研究者结果。该研究者由座落在西德Neuherberg的GSF-东欧国家生存环境和健康研究者中都心的Caren Vollmert, Claudia Lamina, Cornelia Huth, Melanie Kolz, Andreas Schopfer-Wendels, Friedhelm Bongardt, Florian Kronenberg, Hannelore Lowel 和 Thomas Illig；座落在Essen的Duisburg-Essen所学校的Susanne Hahn,Klaus Mann and Onno E. Janssen；Munich的Ludwig Maximilians所学校的H.-Erich Wichmann；Munich 系统设计所学校的Jakob C. Mueller；Dusseldorf的Heinrich Heine所学校的Christian Herder以及GSF-东欧国家生存环境和健康研究者中都心的Rolf Holle共同完成。他们的研究者发表在美国内分泌降解神经科华尔街日报的电子版（）。该华尔街日报是美国神经科不会（APS）（）每月发行的14种科学研究出有版物之一。方法研究者除此以外752名男同开放性恋。其中都，146人确诊为PCOS，其余606人用来作为对照的波兰人来自先前顺利进行的与本研究者无关的一项研究者，且为无关的非糖尿开放性。PCOS组剥离外周血并剥离出来基因组组DNA，大鼠从全血粒细胞中都剥离出来基因组组DNA。鉴定出有8 个CAPN10个体差异质的遗传号：UCSNP-44，-43，-56，ins/del-19（CAPN10 基因组UCSNP-19核糖体的片段，都有DNA基因组组中都的插入或紊乱个体差异），-110， -58， -63，和 -22。研究者工作人员剥离出来了这8个特殊的单核苷酸开放性片断（SNPs）iV；还有牵涉到在人类DNA基因组组的一种微小的表型，因为它们和PCOS，2型号心血管病因或相关症状有关。然后用比较DNA分析的方法做基因组分型号来判定个质对某种病因的表现型缺陷。为估计每个SNPs与PCOS的表现型关联，研究者工作人员定量了病例组和大鼠遗传号分布的相异。还量度了两组中都年龄和质重指数（BMI）的完全相同产生的制约。研究者工作人员用他们自己获得的数据库以及所有的已经发表的能确实CAPN10和PCOS的表现型关联的数据库做了meta-分析，来更多的阐明CAPN10和PCOS的表现型关联。结果研究者工作人员的推测除此以外以下切实：* 有相比的证据确实心血管病因的基因组区域CAPN10 UCSNP-56 和 UCSNP-ins/del-19与PCOS易感开放性有关联。* CAPN10 UCSNP-22和PCOS间有预期关联。* CAPN10 UCSNP-44， -43， -110， -58，or -63和PCOS易感开放性没有特别是在关联。结论本研究者促使为一个基因组的两个区域CAPN10 UCSNP-56 和 UCSNP-ins/del-19与PCOS易感开放性相关的分析方法发放了强有力的支持。这些数据库也确实SNP ins/del-19似乎与PCOS和2型号心血管病因都有关联。这些结果对于约占男同开放性恋人口比例5%，被确诊患有这种疼痛甚至致残的病因的患儿而言是个圣诗。同时，作者们建议顺利进行促使的病例-对照研究者和meta-分析来更多的解释这些结果。 'Diabetes Gene' And Polycystic Ovary Syndrome May Be LinkedMain Category: Diabetes NewsArticle Date: 11 Dec 2006 - 20:00pm (PST)Polycystic ovary syndrome (PCOS) occurs when ovarian cysts block a woman's normal ovulation and menstrual cycle. While the problem sounds straightforward, the disease is complex, born from both multiple genetic components and environmental factors. PCOS affects up to five percent of the female population, and those diagnosed with the disease he a 2- to 7-fold risk of developing type 2 diabetes mellitus (T2DM). For this reason researchers believe a gene related to diabetes may also play a role in the onset of PCOS. A new study of 146 PCOS patients has found that the "diabetes gene" (calpain-10 (CAPN10)) is in fact an interesting candidate for explaining the syndrome. A New Study The findings are contained in a new study entitled "Calpain-10 Variants and Haplotypes are Associated with Polycystic Ovary Syndrome in Caucasians." The study was conducted by Caren Vollmert, Claudia Lamina, Cornelia Huth, Melanie Kolz, Andreas Schopfer-Wendels, Friedhelm Bongardt, Florian Kronenberg, Hannelore Lowel and Thomas Illig, all of the GSF-National Research Center for Environment and Health, Neuherberg; Susanne Hahn, Klaus Mann and Onno E. Janssen, University of Duisburg-Essen, Essen; H.-Erich Wichmann, Ludwig Maximilians University, Munich; Jakob C. Mueller, Technical University, Munich; Christian Herder, Heinrich Heine University, Dusseldorf; and Rolf Holle, GSF-National Research Center of Environment and Health, Neuherberg, Germany. Their study appears in the online edition of the American Journal of Physiology-Endocrinology and Metabolism (). The journal is one of the 14 scientific publications published by the American Physiological Society (APS) () each month. Methodology The study comprised 752 females. Of the total, 146 were diagnosed with PCOS and 606 were unrelated non-diabetic female controls drawn from a previously conducted independent study of the German population. Genomic DNA was taken from the PCOS group and isolated from whole blood, and genomic DNA was extracted from the blood leukocytes of the controls. Eight CAPN10 variants were genotyped: UCSNP-44, -43, -56, ins/del-19 (a fragment of gene CAPN10 UCSNP-19, which contains an insertion or deletion variation in the DNA sequence), -110, -58, -63, and -22. The researchers extracted these eight specific single-nucleotide polymorphisms (SNPs) ¡V the small genetic variations that can occur within a person's DNA sequence because they are known to be associated with PCOS, type 2 diabetes, or related traits. Genotyping using comparative DNA ysis to determine the predisposition of individuals to certain diseases was then performed. To estimate the genetic association of each of the eight SNPs with PCOS the differences in genotype distributions between the case and control groups were measured. The impact of the differences in age and body mass index (BMI) structures for both groups was also calculated. To better clarify the purported associations between CAPN10 and PCOS the researchers performed a meta-ysis using their own data and all ailable published data showing a genetic association between CAPN10 and PCOS. Results Highlights of the researchers' findings include the following: * clear evidence associating the diabetes gene areas CAPN10 UCSNP-56 and UCSNP-ins/del-19 with PCOS susceptibility * an expected association between CAPN10 UCSNP-22 and PCOS * no significant association between CAPN10 UCSNP-44, -43, -110, -58, or -63 and PCOS susceptibility Conclusions This study provides additional strong support for the theory that two areas of one gene ；还有 CAPN10 UCSNP-56 and UCSNP-ins/del-19 ；还有 are related to PCOS susceptibility. These data also suggest that the SNP ins/del-19 may be related to both PCOS and type 2 diabetes.The findings are good news for the estimated five percent of the female population who are diagnosed with the painful and sometimes disabling disease. At the same time, the authors recommend that additional case-control studies and meta-ysis be undertaken to better understand these findings.

撰稿人：蓝色幻想

撰稿人： 张靖